Date of Original Version

9-2014

Type

Article

PubMed ID

26855459

Rights Management

This is the accepted version of the article which has been published in final form at http://dx.doi.org/10.1080/01621459.2014.990973

Abstract or Description

This article introduces false discovery rate regression, a method for incorporating covariate information into large-scale multiple-testing problems. FDR regression estimates a relationship between test-level covariates and the prior probability that a given observation is a signal. It then uses this estimated relationship to inform the outcome of each test in a way that controls the overall false discovery rate at a prespecified level. This poses many subtle issues at the interface between inference and computation, and we investigate several variations of the overall approach. Simulation evidence suggests that: (1) when covariate effects are present, FDR regression improves power for a fixed false-discovery rate; and (2) when covariate effects are absent, the method is robust, in the sense that it does not lead to inflated error rates. We apply the method to neural recordings from primary visual cortex. The goal is to detect pairs of neurons that exhibit fine-time-scale interactions, in the sense that they fire together more often than expected due to chance. Our method detects roughly 50% more synchronous pairs versus a standard FDR-controlling analysis. The companion R package FDRreg implements all methods described in the article. Supplementary materials for this article are available online.

DOI

10.1080/01621459.2014.990973

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Published In

Journal of the American Statistical Association, 110, 510, 459-471.