Title

Neonatal novelty exposure modulates hippocampal volumetric asymmetry in the rat.

Date of Original Version

10-8-2001

Type

Article

PubMed ID

11568629

Abstract or Description

Early life environmental manipulations have been shown to affect hippocampal-dependent learning, hippocampal volume and cerebral lateralization. In this study, we investigated the effects of neonatal stimulation on hippocampal volumetric asymmetry. Long-Evans hooded rats were exposed to a novel non-home environment 3 min daily for the first 3 weeks of life. Histological measures of the left and right hippocampus were made at 8 months of age. We found that neonatal novelty exposure resulted in a long-lasting change in hippocampal volumetric asymmetry. Specifically, this brief and transient early life stimulation increased the right hippocampal volumetric dominance at mid-adulthood.

 

Published In

Neuroreport, 12, 14, 3019-3022.