Date of Original Version

7-2003

Type

Article

Published In

Biophysical Journal, Volume 85, Issue 1, 70-74, 1 July 2003

Abstract or Table of Contents

Osmotic shock is a familiar means for rupturing viral capsids and exposing their genomes intact. The necessary conditions for providing this shock involve incubation in high-concentration salt solutions, and lower permeability of the capsids to salt ions than to water molecules. We discuss here how values of the capsid strength can be inferred from calculations of the osmotic pressure differences associated with measured values of the critical concentration of incubation solution.

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