Title

Volumetric stability of lipid bilayers.

Date of Original Version

11-28-2012

Type

Article

PubMed ID

23069984

Abstract or Description

In agreement with recent reports, a commercial densimeter has yielded a gradual decrease in lipid molecular volume of DPPC multilamellar vesicle dispersions in the gel phase upon repeated thermal cycling between 10 °C and 50 °C. The considerable size of this decrease would have significant implications for the physical chemistry of biomembranes. In contrast, neutral buoyancy measurements performed with similar thermal cycling indicate no gradual change in lipid volume in the gel phase at 20 °C. Remixing the lipid in the densimeter shows that the apparent volume decrease is an artifact. We conclude that gel phase DPPC bilayers exist in a volumetrically stable phase.

DOI

10.1039/C2CP42595E

 

Published In

Physical Chemistry Chemical Physics, 14, 44, 15452-15457.