Date of Original Version
This is the accepted version of the article which has been published in final form at http://dx.doi.org/10.1039/C1CC12805A
Abstract or Description
Guanine-rich peptide nucleic acid probes hybridize to DNA G quadruplex targets with high affinity, forming PNA-DNA heteroquadruplexes. We report a surprising degree of kinetic discrimination for PNA heteroquadruplex formation with a series of DNA targets. The fastest hybridization is observed for targets folded into parallel morphologies.
Chemical communications, 47, 30, 8524-8526.