Date of Original Version

8-14-2011

Type

Article

PubMed ID

21717030

Rights Management

This is the accepted version of the article which has been published in final form at http://dx.doi.org/10.1039/C1CC12805A

Abstract or Description

Guanine-rich peptide nucleic acid probes hybridize to DNA G quadruplex targets with high affinity, forming PNA-DNA heteroquadruplexes. We report a surprising degree of kinetic discrimination for PNA heteroquadruplex formation with a series of DNA targets. The fastest hybridization is observed for targets folded into parallel morphologies.

DOI

10.1039/C1CC12805A

Included in

Chemistry Commons

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Published In

Chemical communications, 47, 30, 8524-8526.