Title

Slow DNA transport through nanopores in hafnium oxide membranes.

Date of Original Version

11-26-2013

Type

Article

PubMed ID

24083444

Abstract or Description

We present a study of double- and single-stranded DNA transport through nanopores fabricated in ultrathin (2-7 nm thick) freestanding hafnium oxide (HfO2) membranes. The high chemical stability of ultrathin HfO2 enables long-lived experiments withhours, in which we observe >50 000 DNA translocations with no detectable pore expansion. Mean DNA velocities are slower than velocities through comparable silicon nitride pores, providing evidence that HfO2 nanopores have favorable physicochemical interactions with nucleic acids that can be leveraged to slow down DNA in a nanopore.

DOI

10.1021/nn404326f

 

Published In

ACS Nano, 7, 11, 10121-10128.