Date of Original Version

9-1-2011

Type

Article

PubMed ID

21795388

Rights Management

© 2011 Bartoli et al. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available under an Attribution-Non-commercial-Share Alike Creative Commons license.

Abstract or Description

The kinesin-related molecular motor Eg5 plays roles in cell division, promoting spindle assembly. We show that during interphase Eg5 is associated with ribosomes and is required for optimal nascent polypeptide synthesis. When Eg5 was inhibited, ribosomes no longer bound to microtubules in vitro, ribosome transit rates slowed, and polysomes accumulated in intact cells, suggesting defects in elongation or termination during polypeptide synthesis. These results demonstrate that the molecular motor Eg5 associates with ribosomes and enhances the efficiency of translation.

DOI

10.1091/mbc.E11-03-0211

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Published In

Molecular biology of the cell, 22, 18, 3420-3430.