Title

Vertebrate evolution: doubling and shuffling with a full deck.

Date of Original Version

1-1-2003

Type

Article

PubMed ID

12493240

Abstract or Description

The number and role of whole-genome duplications in vertebrate evolution has intrigued evolutionary biologists since Ohno first proposed genome duplication as the force driving the 'big leap' in vertebrate morphological innovation. Attempts to resolve these issues have been thwarted by small and noisy datasets, and by lack of computational accuracy and statistical rigor. Recently, Ken Wolfe and colleagues presented a genome-scale, statistically rigorous analysis of evidence based on the spatial organization of duplicated genes, as well as estimates of duplication times. Their results provide the strongest evidence to date of large-scale duplication throughout the vertebrate genome, consistent with at least one whole-genome duplication.

DOI

10.1016/S0168-9525(02)00008-2

 

Published In

Trends in genetics : TIG, 19, 1, 2-5.