Title

Comparative immunopeptidomics of humans and their pathogens.

Date of Original Version

9-7-2004

Type

Article

PubMed ID

15326311

Abstract or Description

Major histocompatibility complex class I molecules present peptides of 8-10 residues to CD8+ T cells. We used 19 predicted proteomes to determine the influence of CD8+ T cell immune surveillance on protein evolution in humans and microbial pathogens by predicting immunopeptidomes, i.e., sets of class I binding peptides present in proteomes. We find that class I peptide binding specificities (i) have had little, if any, influence on the evolution of immunopeptidomes and (ii) do not take advantage of biases in amino acid distribution in proteins other than the concentration of hydrophobic residues in NH(2)-terminal leader sequences.

DOI

10.1073/pnas.0404740101

 

Published In

Proceedings of the National Academy of Sciences of the United States of America, 101, 36, 13268-13272.