Title

Fungal Biofilms, Drug Resistance, and Recurrent Infection.

Date of Original Version

1-1-2014

Type

Article

PubMed ID

25274758

Abstract or Description

A biofilm is a surface-associated microbial community. Diverse fungi are capable of biofilm growth. The significance of this growth form for infection biology is that biofilm formation on implanted devices is a major cause of recurrent infection. Biofilms also have limited drug susceptibility, making device-associated infection extremely difficult to treat. Biofilm-like growth can occur during many kinds of infection, even when an implanted device is not present. Here we summarize the current understanding of fungal biofilm formation, its genetic control, and the basis for biofilm drug resistance.

DOI

10.1101/cshperspect.a019729

 

Published In

Cold Spring Harbor Perspectives in Medicine, 4, 10.