Title

Retrograde trafficking of AB₅ toxins: mechanisms to therapeutics.

Date of Original Version

10-1-2013

Type

Article

PubMed ID

23665994

Abstract or Description

Bacterial AB5 toxins are a clinically relevant class of exotoxins that include several well-known members such as Shiga, cholera, and pertussis toxins. Infections with toxin-producing bacteria cause devastating human diseases that affect millions of individuals each year and have no definitive medical treatment. The molecular targets of AB5 toxins reside in the cytosol of infected cells, and the toxins reach the cytosol by trafficking through the retrograde membrane transport pathway that avoids degradative late endosomes and lysosomes. Focusing on Shiga toxin as the archetype member, we review recent advances in understanding the molecular mechanisms involved in the retrograde trafficking of AB5 toxins and highlight how these basic science advances are leading to the development of a promising new therapeutic approach based on inhibiting toxin transport.

DOI

10.1007/s00109-013-1048-7

 

Published In

Journal of Molecular Medicine, 91, 10, 1131-1141.