Title

Fast-spiking interneurons have an initial orientation bias that is lost with vision.

Date of Original Version

9-1-2011

Type

Article

PubMed ID

21750548

Abstract or Description

We found that in mice, following eye opening, fast-spiking, parvalbumin-positive GABAergic interneurons had well-defined orientation tuning preferences and that subsequent visual experience broadened this tuning. Broad inhibitory tuning was not required for the developmental sharpening of excitatory tuning but did precede binocular matching of excitatory orientation tuning. We propose that experience-dependent broadening of inhibition is a candidate for initiating the critical period of excitatory binocular plasticity in developing visual cortex.

DOI

10.1038/nn.2890

 

Published In

Nature neuroscience, 14, 9, 1121-1123.