Title

AC-1 and synaptic development.

Date of Original Version

1-1-2012

Type

Response or Comment

PubMed ID

22210283

Abstract or Description

Across many developing brain structures, axons initially grow toward, and synapse exuberantly with, target neurons before the later removal of excess inputs. In many cases, this input pruning leads to a remarkable specificity, where a single target is innervated by only one axon. This phenomenon has been observed at the neuromuscular junction, the climbing fibre to Purkinje cell synapse in the cerebellum, and also at relay synapses in the thalamus.

DOI

10.1113/jphysiol.2011.223396

 

Published In

The Journal of physiology, 590, Pt 1, 3-3.